尿吡啶酚、尿脱氧吡啶酚、尿氨基末端肽在转移性骨肿瘤中的诊断意义

目的: 评价骨吸收标志物尿吡啶酚(uPyd)、尿脱氧吡啶酚(uDpd)、尿氨基末端肽(uNTx)对骨转移癌的诊断意义。方法: 晚期肿瘤患者80例,其中伴有骨转移者46例。定量测定uPyd、uDpd、uNTx,同时记录骨痛程度及骨转移范围。结果: 有无骨转移两组患者uPyd、uDpd、uNTx水平比较差异均有统计学意义(P<0.01),其中uNTx有较高的诊断准确性;不同程度骨痛uPyd水平差异无统计学意义(P>0.05),而uDpd、uNTx水平差异均有统计学意义(P<0.01);而不同程度骨转移范围uPyd、uDpd、uNTx水平差异亦有统计学意义(P<0.01)。结论: uPyd、uDpd、uNTx对肿瘤患者骨转移有一定的辅助诊断价值。uPyd、uDpd、uNTx水平能在一定程度上反映骨痛程度和骨转移范围。

Diagnostic value of urinary pyridol,urinary deoxypyridinoline and urinary N terminal telopeptide in cancer patients with bone metastases

Objective: To assess the value of urinary pyridol(uPyd),urinary deoxypyridinoline(uDpd) and urinary N terminal telopeptide opeptide(uNTx) in diagnosis of patients with bone metastases.Methods: Eighty advanced cancer patients were included in the study and bone metastases were noted in 46 of them.The uPyd,uDpd and uNTx were measured in all the cases,and the severity of bone pain and the extent of bone involvement were recorded.Results: The levels of uPyd,uDpd,and uNTx were statistially different in patients with bone involvement and those without bone involvement,and uNTx provided a higher diagnostic accuracy.The level of uPyd was not related to the severity of bone pain,while the levels of uDpd and uNTx were.The levels of uPyd,uDpd,and uNTx were greatly different in patients with bone metastases(P<0.01).Conclusions: Detection of uPyd,uDpd and uNTx has certain diagnostic value in cancer patients with bone metastases.The level of uPyd,uDpd and uNTx may reveal the sevierity of bone pain and the extent of bone involvement.