左旋卡尼汀与红细胞生成素合用可提高维持性血液透析患者的透析耐受性

目的 :观察左旋卡尼汀与红细胞生成素 (EPO)合用对维持性血液透析 (HD)患者透析耐受性的影响。方法 :选择HD患者 2 6例 ,随机分为A、B两组 ,每次透析结束后A组静脉注射左旋卡尼汀 1g。B组除左旋卡尼汀外 ,给予EPO12 0u/kg·w ,皮下注射。 10周分别观察治疗前后临床症状及血液、生化指标的变化。结果 :两组体力、精神状态、食欲、透析中肌痉挛、低血压等症状都有改善 ,B组改善更明显。与A组比 ,B组的干体重及血浆蛋白升高显著 (P <0 .0 5 ) ,血红蛋白 ,血球压积变化差异更显著 (P <0 .0 1)。结论 :两药合用可提高HD患者的透析耐受性。

To integrate L-carnitine with erythropoietin can improve maintenance hemodialysis patients' dialysis tolerance

Objective: To investigate the influence on maintenance hemodialysis patients' dialysis tolerance of integrating L-carnitine with erythropoietin(EPO). Method: Twenty-six maintenance hemodialysis patients were divided into two groups: A and B .in group A(n=13),1g of L-carnitine was infused to the patients at the and end of each hemodialysis treatment. In group B(n=13) apart from L-carnitine, Epo (120u/kg,each week)was infused to the patients for ten weeks. The improvement of clinical symptom, blood and biochemistry target were observed separately.Result: Both of them were improved in physical and mental status, appetite, intra-dialytic hypotension and cramps, the group B was improved significantly. Net weight, hemoglobin, hemotocrit and serum albumin were rising, and the group B was rising significantly. Conclusion: To integrate L-carnitine with Epo can improve maintenance hemodialysis patients' dialysis tolerance.