Immunoreactive substance P in sympathetic ganglia: distribution and sensitivity towards capsaicin |
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| Authors: | R Gamse A Wax R E Zigmond S E Leeman |
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| Affiliation: | 1. Laboratory of Human Reproduction and Reproductive Biology, Department of Physiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, U.S.A.;2. Department of Pharmacology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, U.S.A. |
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| Abstract: | The distribution of immunoreactive substance P was studied in sympathetic ganglia of guinea-pigs and rats. In both species the highest concentration was found in the coeliac-superior mesenteric ganglion. Guinea-pigs had three times higher concentrations of immunoreactive substance P than rats in all ganglia studied. Pretreatment of guinea-pigs with capsaicin (125 mg/kg; s.c.), an agent shown to deplete immunoreactive substance P only from primary sensory neurons, caused a 63–96% depletion of immunoreactive substance P in sympathetic ganglia and the splanchnic nerve. Superfusion of coeliac ganglia with capsaicin (3.3 × 10?5M) in vitro led to a calcium-dependent release of immunoreactive substance P.The findings that capsaicin causes release and depletion of immunoreactive substance P from sympathetic ganglia support the hypothesis that substance P-containing fibers in sympathetic ganglia are primary sensory neurons. |
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| Keywords: | Present address and address for correspondence: Department of Pharmacology University of Graz Universitätsplatz 4 A-8010 Graz Austria. |
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