| 蝙蝠葛碱对豚鼠心室肌细胞L型钙电流阻断作用 |
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| 引用本文： | 郭东林,周兆年.蝙蝠葛碱对豚鼠心室肌细胞L型钙电流阻断作用[J].中国药理学报,1997,18(5):419-421. |
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| 作者姓名： | 郭东林 周兆年 |
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| 作者单位： | [1]同济医科大学临床药理研究所 [2]中国科学院上海生理研究所 |
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| 摘 要： | 目的：研究蝙蝠葛碱对豚鼠心室肌细胞Ｌ型钙电流的阻断作用及其特性。方法：利用全细胞记录方法，记录单个豚鼠心室肌细胞Ｌ型钙电流。结果：蝙蝠葛碱１，１０，１００μｍｏｌ·Ｌ＾－１可使钙电流分别减少１５．２％±２．２％，４１％±５％，８２％±８％。冲洗后，可使钙电流部分恢复，蝙蝠葛碱具有浓度依赖性阻断钙电流的作用。在刺激频率３Ｈｚ与１Ｈｚ，其阻断钙电流的程序相似。结论：蝙蝠葛碱具有阻断Ｌ型钙电流的作用。
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| 关 键 词： | 蝙蝠葛碱 钙通道 心肌 |
Dauricine inhibited L-type calcium current in single cardiomyocyte of guinea pig. |
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| D L Guo,Z N Zhou,F D Zeng,C J Hu.Dauricine inhibited L-type calcium current in single cardiomyocyte of guinea pig.[J].Acta Pharmacologica Sinica,1997,18(5):419-421. |
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| Authors: | D L Guo Z N Zhou F D Zeng C J Hu |
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| Institution: | Institute of Clinical Pharmacology, Tongji Medical University, Wuhan, China. |
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| Abstract: | AIM: To study the effect of dauricine (Dau) on L-type calcium current in guinea pig ventricular myocytes. METHODS: Using whole-cell recording method to record L-type calcium current (ICa) in single ventricular cell of guinea pig. RESULTS: Dau 1, 10, and 100 mumol.L-1 markedly reduced ICa by 15.2% +/- 2.2%, 41% +/- 5%, and 82% +/- 8%, respectively. After washing out, ICa partially recovered. Dau inhibited ICa at 3 Hz and 1 Hz to a similar extent, its effect on ICa appeared to be not frequency-dependent. CONCLUSION: Dau had a calcium channel blocking effect. |
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