| 前胡丙素对分离的成年鼠正常及肥厚心室肌细胞内游离钙的影响 |
| |
| 引用本文： | 孙兰,王金唏.前胡丙素对分离的成年鼠正常及肥厚心室肌细胞内游离钙的影响[J].中国药理学报,1997,18(3):251-254. |
| |
| 作者姓名： | 孙兰 王金唏 |
| |
| 作者单位： | [1]南京医科大学基础医学院心血管药理研究室 [2]南京大学化工学院配位学研究所 |
| |
| 摘 要： |
|
| 关 键 词： | 前胡丙素 钙 左室肥厚 |
Effects of praeruptorine C on the intracellular free calcium in normal and hypertrophied rat ventricular myocytes. |
| |
| L Sun,M R Rao,J X Wang.Effects of praeruptorine C on the intracellular free calcium in normal and hypertrophied rat ventricular myocytes.[J].Acta Pharmacologica Sinica,1997,18(3):251-254. |
| |
| Authors: | L Sun M R Rao J X Wang |
| |
| Institution: | Department of Cardiovascular Pharmacology, Nanjing Medical University, China. |
| |
| Abstract: | AIM: To study the intracellular free calcium (Ca2+]i) in normal and hypertrophic left ventricular myocytes isolated from adult rat hearts and the effects of praeruptorine C (Pra-C) on them. METHODS: Ca2+]i of single myocyte was measured with Fura 2-AM. RESULTS: The resting Ca2+]i was 87 +/- 4 nmol.L-1 in normal left ventricular myocytes, 123 +/- 7 nmol.L-1 in hypertrophied myocytes. After exposure to KCl (20, 40, and 60 mmol.L-1), the Ca2+]i were increased by 66%, 141%, and 268% in normal myocytes, and 77%, 185%, and 243% in hypertrophic myocytes, respectively. Pra-C (1, 10, and 100 mumol.L-1) concentration-dependently inhibited the Ca2+]i elevation caused by KCl (35 mmol.L-1) or norepinephrine (20 mumol.L-1) in both normal and hypertrophied myocytes. All of the effects of Pra-C were similar to that of nifedipine. CONCLUSION: Ca2+]i of hypertrophied myocytes was higher than that of normal ones and Pra-C decrease the Ca2+]i elevation in left ventricular myocytes resulted from its calcium channel blockade. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
|
