| 前胡丙素对培养新生鼠心肌细胞自发性[Ca^2＋]i瞬间变化的影响 |
| |
| 引用本文： | 王洪新,王金唏.前胡丙素对培养新生鼠心肌细胞自发性[Ca^2＋]i瞬间变化的影响[J].中国药理学报,1997,18(1):81-84. |
| |
| 作者姓名： | 王洪新 王金唏 |
| |
| 作者单位： | [1]南京医科大学心血管药理研究室 [2]南京大学配位化学国家重点实验室 |
| |
| 摘 要： |
|
| 关 键 词： | 前胡丙素 心肌细胞 钙 细胞培养 |
Effect of praeruptorin C on spontaneous [Ca2+]i transients in cultured myocardial cells of neonatal rats. |
| |
| H X Wang,M R Rao,J X Wang,S J Yang.Effect of praeruptorin C on spontaneous [Ca2+]i transients in cultured myocardial cells of neonatal rats.[J].Acta Pharmacologica Sinica,1997,18(1):81-84. |
| |
| Authors: | H X Wang M R Rao J X Wang S J Yang |
| |
| Institution: | Department of Cardiovascular Pharmacology, Nanjing Medical University, China. |
| |
| Abstract: | AIMS: To study the effects of praeruptorin C (Pra-C) on Ca2+]i transients in cultured neonatal myocardiocytes. METHOD: Using Ca(2+)-sensitive fluorescent indicator, Fura 2-AM, spontaneous cytosolic Ca2+ transients were measured in cultured myocardial cells of neonatal rats. RESULTS: Pra-C 10, 30 mumol.L-1 caused a decrease in the peak of Ca2+ transients. Pra-C 30 mumol.L-1 and 10-30 mumol.L-1 inhibited partly the stimulatory effects of CaCl2 4.8 mmol.L-1 and Bay k 8644 100 nmol.L-1 on peak Ca2+ transients, respectively. Pra-C did not cause any marked change in the basal Ca2+]i level between beats. Pra-C inhibited the reduced Ca2+]i transients after inhibition of sarcoplasmic reticulum Ca2+ release in ryanodine pretreated cells. CONCLUSIONS: Pra-C inferred with the Ca2+ influx responsible for excitation-contraction coupling in myocardiocytes. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
