| 糖尿病大鼠血中内源性一氧化氮合酶抑制物增高 |
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| 引用本文： | 熊燕,鲁蓉.糖尿病大鼠血中内源性一氧化氮合酶抑制物增高[J].中国药理学报,1997,18(6):511-514. |
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| 作者姓名： | 熊燕 鲁蓉 |
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| 作者单位： | 湖南医科大学药理教研室 |
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| 摘 要： | 目的：测定糖尿病大鼠血中内源性ＮＯ合酶抑制物二甲基精氨酸（ＤＭＡ）的含量，方法：在链佐星诱发的糖尿病大鼠测定血清ＤＭＡ的含量和乙酰胆碱（ＡＣｈ）诱导血管内皮依赖性舒张，结果：与对照组相比，糖尿病大鼠ＤＭＡ血清浓度显增加（５．４±１．０ｖｓ０．７±０．３μｍｏｌ．Ｌ＾－１，Ｐ〈０．０１）；丙二醛含量也高于对照组（２．５±０．３ｖｓ２１．５±０．１μｍｏｌ．Ｌ＾－１，Ｐ〈０．０１）；糖尿病大鼠ＡＣｈ
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| 关 键 词： | 精氨酸 糖尿病 一氧化氮合酶 抑制物 |
Elevation of an endogenous inhibitor of nitric oxide synthase in diabetic rat serum. |
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| Y Xiong,R Lu,Y J Li,H W Deng.Elevation of an endogenous inhibitor of nitric oxide synthase in diabetic rat serum.[J].Acta Pharmacologica Sinica,1997,18(6):511-514. |
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| Authors: | Y Xiong R Lu Y J Li H W Deng |
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| Institution: | Department of Pharmacology, Hunan Medical University, Changsha, China. |
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| Abstract: | AIM: To study the endogenous inhibitor of NO synthase NG,NG-dimethyl-arginine (DMA) in the diabetic rat serum. METHODS: In streptozocin-induced diabetic rats, the serum DMA level and endothelium-dependent vasorelaxation to acetylcholine (ACh) were determined. RESULTS: The serum DMA concentration was increased in the diabetic rats compared with their age-matched controls (5.4 +/- 1.0 vs 0.7 +/- 0.3 mumol.L-1, P < 0.01). The serum malondialdehyde (MDA) level was also increased in the diabetic rats compared with controls (2.5 +/- 0.3 vs 1.5 +/- 0.1 mumol.L-1, P < 0.01). Vasodilator response to ACh was impaired in diabetic thoracic aortas, which was improved by preincubation with L-arginine 1 mmol.L-1. CONCLUSION: Hyperglycemia elevated the endogenous DMA content, which contributed to attenuated endothelium-dependent vasorelaxation in streptozocin-induced diabetic rats. |
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