| 卡托普利和依好普利拉对缺氧和复氧心肌细胞内Ca^2＋,Na^＋和pH值的影响 |
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| 引用本文： | 王军 章鲁. 卡托普利和依好普利拉对缺氧和复氧心肌细胞内Ca^2＋,Na^＋和pH值的影响[J]. 中国药理学报, 1997, 18(2): 140-142 |
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| 作者姓名： | 王军 章鲁 |
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| 作者单位： | 上海第二医科大学药理教研室 |
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| 摘 要： |
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| 关 键 词： | 卡托普利 依那普利拉 钙 钠 缺氧 心肌细胞 |
Effects of captopril and enalaprilat on intracellular Ca2+, Na+ contents and pH in hypoxic and reoxygenated cardiomyocytes. |
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| J Wang,P J Zhang,L Zhang,J H Qi,P J Wei,Z J Jin. Effects of captopril and enalaprilat on intracellular Ca2+, Na+ contents and pH in hypoxic and reoxygenated cardiomyocytes.[J]. Acta Pharmacologica Sinica, 1997, 18(2): 140-142 |
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| Authors: | J Wang P J Zhang L Zhang J H Qi P J Wei Z J Jin |
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| Affiliation: | Department of Pharmacology, Shanghai Second Medical University, China. |
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| Abstract: | AIM: To study the mechanisms of captopril (Cap) and enalaprilat (Ena) protective effects on hypoxic and reoxygenated cardiac myocytes. METHODS: Using fluorescent probes Fura 2-AM, BCECF/AM, SBFI/AM combined with computer image processing techniques to measure intracellular ion concentrations. RESULTS: [Ca2+]i (165 +/- 8 nmol.L-1) and [Na+]i (9.2 +/- 0.8 mmol.L-1) were higher but [pH]i (6.7 +/- 0.3) was lower in hypoxic and reoxygenated myocytes (196 +/- 14 nmol.L-1, 9.3 +/- 1.3 mmol.L-1, 6.61 +/- 0.19, respectively) than in normal ones. Cap and Ena reduced [Ca2+]i (149 +/- 11 and 152 +/- 10 nmol.L-1 respectively) and intracellular acidosis (7.11 +/- 0.22 and 7.2 +/- 0.4, respectively) during hypoxia. Cap also decreased [Na+]i in hypoxic myocytes (8.1 +/- 0.9 mmol.L-1). During reoxygenation, Cap decreased [Ca2+]i and [Na+]i but Ena had no significant effect on them. Cap or Ena had no additive effect when combined with verapamil (Ver). CONCLUSION: Cap and Ena protected hypoxic and reoxygenated cardiomyocytes, but the mechanisms were not the same. |
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