| 正常人和心脏病患者血清α1—酸性糖蛋白,唾液酸及丙吡胺蛋白… |
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| 引用本文： | 初建设,岸野吏志.正常人和心脏病患者血清α1—酸性糖蛋白,唾液酸及丙吡胺蛋白…[J].中国药理学报,1997,18(5):408-410. |
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| 作者姓名： | 初建设 岸野吏志 |
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| 作者单位： | 北海道大学医学院附属医院药剂部 |
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| 摘 要： | 目的：研究日本人充血性心力衰竭（ＣＨＦ）和急性心肌梗塞（ＡＭＩ）病人对血清α１－酸性糖蛋白（ＡＧＰ）、唾液酸（ＳＡ）浓度及ＡＧＰ与丙吡胺（Ｄｉｓ）结合的影响。方法：对正常人、ＣＨＦ及ＡＭＳ患者血清样本９７例，采用免疫化学法测定ＡＧＰ浓度，高效液相层析法测定ＳＡ浓度及超滤膜技术和高效液相层析法测定Ｄｉｓ的体外游离浓度。结果：ＣＨＦ及ＡＭＩ患者血清ＡＧＰ浓度较正常人升高。Ｄｉｓ药物游离浓度降低。血清Ｓ
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| 关 键 词： | 糖蛋白 心脏病 丙吡胺 唾液酸 蛋白结合率 |
Serum alpha 1-acid glycoprotein, sialic acid, and protein binding of disopyramide in normal subjects and cardiac patients. |
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| J S Chu,S Kishion,A Nomura,K Miyazaki.Serum alpha 1-acid glycoprotein, sialic acid, and protein binding of disopyramide in normal subjects and cardiac patients.[J].Acta Pharmacologica Sinica,1997,18(5):408-410. |
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| Authors: | J S Chu S Kishion A Nomura K Miyazaki |
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| Institution: | Department of Pharmacy, Hokkaido University Hospital, School of Medicine, Hokkaido University, Sapporo, Japan. |
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| Abstract: | AIM: To study influence of congestive heart failure (CHF) and acute myocardial infarction (AMI) on alpha 1-acid glycoprotein (AGP) and sialic acid (SA) concentration, and binding of AGP to disopyramide (Dis). METHODS: Sera from 85 healthy subjects, 6 patients with CHF, and 6 patients with AMI were determined by immunochemistry for AGP, by HPLC method for sialic acid (SA), and by ultrafiltration and HPLC for the free fraction of Dis. RESULTS: Serum AGP concentrations (g.L-1) were 0.74 +/- 0.16 (healthy), 1.18 +/- 0.40 (d 1, CHF) and 0.90 +/- 0.24 (d 14, CHF), 1.53 +/- 0.26 (d 5, AMI) and 1.08 (d 14, AMI). The free Dis were 1.76 +/- 0.62 (d 1) and 2.14 +/- 0.48 (d 14), in CHF patients, 1.66 +/- 0.52 (d 5) and 1.77 (d 14) in AMI patients. The changes of serum SA and AGP concentrations showed the same tendency. CONCLUSION: The free Dis in serum was affected by the change of AGP binding in CHF and AMI patients. |
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