| 神经激肽—1受体拮抗剂SR—140333对镇静大鼠乙酰甲胆碱气道反应… |
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| 引用本文： | 田炯,魏尔清.神经激肽—1受体拮抗剂SR—140333对镇静大鼠乙酰甲胆碱气道反应…[J].中国药理学报,1997,18(6):485-488. |
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| 作者姓名： | 田炯 魏尔清 |
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| 作者单位： | 浙江医科大学 |
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| 摘 要： | 目的：探讨神经激肽对乙酰甲胆碱（ＭＣ）气道反应性的作用。方法：观察非肽类ＮＫ－１受体拮抗剂ＳＲ－１４０３３３对镇静大鼠的ＭＣ气道反应性和离体气管条的收缩反应结果：ＳＲ－１４０３３３抑制ＭＣ气雾（１０－１０００μｍｏｌ／ｍ＾３）引起的呼吸频率增快，抑制ＭＣ气雾（１ｍｍｏｌ／ｍ＾３）反应的ＩＤ５０为４．９（１．４－１７．２μｇ．ｋｇ＾－１）；ＳＲ－１４０３３３１μｍｏｌ．Ｌ＾－１对乙酰甲胆碱引起的气管
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| 关 键 词： | SR－140333 乙酰甲胆碱 神经激肽1 受体 气道反应 |
Effect of SR-140333, a neurokinin-1 receptor antagonist, on airway reactivity to methacholine in sedated rats. |
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| J Tian,E Q Wei,J S Chen,W P Zhang.Effect of SR-140333, a neurokinin-1 receptor antagonist, on airway reactivity to methacholine in sedated rats.[J].Acta Pharmacologica Sinica,1997,18(6):485-488. |
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| Authors: | J Tian E Q Wei J S Chen W P Zhang |
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| Institution: | Laboratory of Neurobiology, Department of Pharmacology, Zhejiang Medical University, Hangzhou, China. |
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| Abstract: | AIM: To study the roles of neurokinins in the airway reactivity (AR) to methacholine chloride (MC). METHODS: The effects of (S)-1-(2-3, 4-dichlorophenyl)-1-(3-isopropoxyphenylacetyl) piperidin-3-yl]ethyl)-4-phenyl-1-azoniabicyclo 2.2.2]octane.chloride (SR-140333), a neurokinin-1 receptor antagonist, on AR to inhaled MC in diazepam-sedated rats, and on MC-induced contraction of isolated tracheal spiral strips were observed. RESULTS: SR-140333 inhibited the increase in respiratory rate (RR) induced by MC aerosol (10-1000 mumol/m3), and the ID50 for inhibiting the response to MC aerosol (1 mmol/m3) was 4.9 micrograms.kg-1 (95% confidence limits 1.4-17.2 micrograms.kg-1). SR-140333 1 mumol.L-1 had no inhibitory effect on MC-induced tracheal contraction. Atropine blocked responses to MC both in vivo and in vitro. CONCLUSION: Endogenous neurokinins are involved in the AR to MC in rats, at least partly mediated via neurokinin-1 receptors. |
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