| 组胺对豚鼠左甲状腺素诱导的心肌病的影响 |
| |
| 引用本文： | 胡慧娟 戴德哉. 组胺对豚鼠左甲状腺素诱导的心肌病的影响[J]. 中国药理学报, 1997, 18(2): 159-160 |
| |
| 作者姓名： | 胡慧娟 戴德哉 |
| |
| 作者单位： | 中国药科大学中药药理教研室 |
| |
| 摘 要： |
|
| 关 键 词： | 左甲状腺素 组胺 心肌病 |
Histamine aggravated levothyroxine-induced cardiomyopathy in guinea pigs. |
| |
| H J Hu,D Z Dai,Y M Shen. Histamine aggravated levothyroxine-induced cardiomyopathy in guinea pigs.[J]. Acta Pharmacologica Sinica, 1997, 18(2): 159-160 |
| |
| Authors: | H J Hu D Z Dai Y M Shen |
| |
| Affiliation: | Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China. |
| |
| Abstract: | AIM: To study effects of histamine on cardiomyopathy. METHODS: Cardiomyopathy model was developed in guinea pig by i.p. levothyroxine 0.5 mg.kg-1.d-1 for 10 d. Langendroff's hearts were perfused. ECG and contractile force were recorded. Histamine (5 micrograms) was given by intra-aortic injection. Histamine content of coronary venous effluent was determined fluorometrically. RESULTS: Attack of histamine on cardiomyopathy was severer than that in normal hearts. Tachycardia was more prominent; atrioventricular conduction block occurred earlier; decrease in coronary flow was more marked. Uptakes of histamine were 37% in the model and 19% in the normal hearts (P < 0.01). CONCLUSION: Histamine aggravated levothyroxine-cardiomyopathy. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
|
