| 蝙蝠葛碱,硅尼丁和索他洛尔对离体乳头状肌动作电位时程的作用 |
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| 引用本文： | 郭东林,曾繁典.蝙蝠葛碱,硅尼丁和索他洛尔对离体乳头状肌动作电位时程的作用[J].中国药理学报,1997,18(4):348-350. |
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| 作者姓名： | 郭东林 曾繁典 |
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| 作者单位： | 同济医科大学临床药理研究所 |
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| 摘 要： | 目的：观察蝙蝠葛碱对豚鼠乳头状肌的动作电位是否具有使用依赖性特征，并与奎尼丁，索他洛尔作平行比较。方法；利用细胞内微电极技术记录豚鼠乳头状肌跨膜动作电位。结果：蝙蝠葛碱２０μｍｏｌ．Ｌ＾－１能明显延长乳头状肌跨膜动作电位时程，在刺激周长为２００，３００，４００，６００，８００，１０００，２０００ｍｓ时，其延长动作电位时程的百分率分别为２２±８，１１±６，９±５，７±５，６±３，４．３±２．８，４．
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| 关 键 词： | 蝙蝠葛碱 硅尼丁 索他洛尔 乳头状肌 |
Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro. |
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| D L Guo,F D Zeng,C J Hu.Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro.[J].Acta Pharmacologica Sinica,1997,18(4):348-350. |
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| Authors: | D L Guo F D Zeng C J Hu |
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| Institution: | Institute of Clinical Pharmacology, Tongji Medical University, Wuhan, China. |
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| Abstract: | AIM: To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD). METHODS: Using intracellular microelectrode method to record APD in guinea pig papillary muscles. RESULTS: Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence. CONCLUSSION: The effect of dauricine on APD depends on activation frequency. |
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