三水地区女性生殖道支原体感染状况及耐药性变迁

目的了解本地区女性生殖道支原体感染状况及耐药性变迁,为临床合理用药提供参考。方法使用支原体培养及药敏试剂盒对2008～2010年妇科门诊生殖道炎性反应女性患者进行支原体培养鉴定及药敏试验,并对结果进行统计分析。结果近三年7 020例女性生殖道炎性反应患者中支原体检出率为40.6%,呈逐年上升:2008年(37.4%),2009年(38.4%),2010年(43.8%);三种类型的支原体感染构成比:UU占78.1%、MH占2.7%、UU合并MH占19.2%,以UU感染为主;支原体感染年龄分布:86.0%集中在20～40岁,以20～30岁为主(占56.6%);耐药监测结果表明:UU、MH及UU合并MH对美满霉素、强力霉素、交沙霉素敏感性最高,单纯UU感染克拉霉素敏感性也很高,而MH及UU合并MH对大环内酯类的罗红霉素、阿奇霉素、克拉霉素的耐药率都达到90%以上;喹诺酮类药物敏感性普遍较低,罗红霉素敏感性处于众药的最低水平;2010年与前两年相比,UU的耐药性普遍升高了,以交沙霉素、左氧氟沙星最为明显,差异有统计学意义(p<0.01)。结论支原体在女性生殖道炎性患者中感染率较高,以UU为主。支原体感染及耐药性在变迁,单纯UU、MH及UU合并MH的耐药性存在很大的差异,临床治疗支原体感染应根据鉴定及药敏试验结果,合理用药,减少耐药菌株产生。

CHANGES IN DRUG RESISTANCE OF MYCOPLASMA AND THE STATUS OF MYCOPLASMA IN GENITAL TRACT INFECTION IN THE FEMALE IN SANSHUI AREA

Objective To present reference for clinical rational drug application through the investigation of the status of Mycoplasma in genital tract infection in the female within this locality and the changes in drug resistance of Mycoplasma.Methods Mycoplasma culture and drug susceptibility kits were applied to the 2008~2010 gynecological clinic female genital tract inflammation in patients to conduct Mycoplasma identification and drug sensitivity test,and the results were statistically analyzed.Results In the 7 ...