| 乙肝病毒X蛋白对肝细胞生物钟基因的影响及其意义 |
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| 作者单位： | Department of General Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China |
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| 摘 要： |
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| 关 键 词： | 肝细胞 生物钟基因 蛋白 乙肝病毒 |
| 收稿时间： | 2005-01-30 |
The influence of hepatitis B virus X protein on the clock genes in liver cells and its significance |
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| Shengli Yang,Xiaoli Pan,Zhifan Xiong,Bo Wei,Hongyi Yao. The influence of hepatitis B virus X protein on the clock genes in liver cells and its significance[J]. The Chinese-German Journal of Clinical Oncology, 2011, 10(8): 468-471. DOI: 10.1007/s10330-011-0826-3 |
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| Authors: | Shengli Yang Xiaoli Pan Zhifan Xiong Bo Wei Hongyi Yao |
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| Affiliation: | (Department of General Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China) ; |
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| Abstract: | Objective:The aim of this study was to investigate the influence of hepatitis B virus X protein (HBx) on the clock genes in LO2 cells and its significance.Methods:A cell line LO2-HBx,Stably transfected with HBx gene,was established.The levels of mRNA and protein expression of CLOCK and BMAL1 were detected by real-time PCR and western blot.Results:The expression of CLOCK mRNA and protein were increased in cell line LO2-HBx (P<0.05),while the expression of BMAL1 mRNA and protein were decreased in cell line LO... |
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| Keywords: | hepatitis B virus X protein (HBx) circadian clock CLOCK BMAL1 hepatic carcinoma |
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