| 尖锐湿疣患者治疗前后血清MIF和HMGB1检测的临床意义 |
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| 引用本文： | 王晓岩,黄友敏,周永勤.尖锐湿疣患者治疗前后血清MIF和HMGB1检测的临床意义[J].中国热带医学,2011,11(4):472-473. |
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| 作者姓名： | 王晓岩 黄友敏 周永勤 |
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| 作者单位： | 1. 北京市煤炭总医院检验科,北京,100028
2. 济宁医学院附属藤州市中心人民医院,山东济宁,2172000 |
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| 摘 要： | 目的探讨尖锐湿疣患者治疗前后血清巨噬细胞移动抑制因子（MIF）和高迁移率蛋白-1（HMGB1）水平的变化及意义。方法采用酶联免疫（ELISA）法检测血清MIF和HMGB1含量；分别对62例尖锐湿疣患者进行了血清MIF和HMGB1检测，并与35名正常健康人作比较。结果在治疗前尖锐湿疣患者MIF和HMGB1水平均非常显著高于正常人组（P〈0．01）。经3个月治疗后血清MIF和HMGB1水平与正常人组比较无显著性差异（尸〉O．05）。患者组治疗前后血清MIF和HMGB1水平也有显著性差异（P〈0．01）。尖锐湿疣患者血清HMGB1浓度与MIF浓度呈正相关（r=033，P〈0．01）。结论检测尖锐湿疣患者血清MIF和HMGB1水平的变化对改病的治疗。预后观察有重要的临床价值。
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| 关 键 词： | 尖锐湿疣 巨噬细胞移动抑制因子 高迁移率蛋白-1 |
Significance of determination of changes of macrophage migration inhibitory factor(MIF)and high mobility group box-1(HMGB1)levels in patients with Condyloma acuminatum |
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| WANG Xiao-yan,HUNG You-min,ZHOU Yong-qin.Significance of determination of changes of macrophage migration inhibitory factor(MIF)and high mobility group box-1(HMGB1)levels in patients with Condyloma acuminatum[J].China Tropical Medicine,2011,11(4):472-473. |
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| Authors: | WANG Xiao-yan HUNG You-min ZHOU Yong-qin |
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| Institution: | WANG Xiao-yan,HUNG You-min,ZHOU Yong-qin.(Department of Urology,Coal General Hospitol,Beijing 100028,P.R.China) |
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| Abstract: | Aim To explore the significance of changes of serum macrophage migration inhibitory factor(MIF)and high mobility group box-1(HMGB1) levels in patients with Condyloma acuminatum before and after treatment.Methods The concentrations of MIF and HMGB1 were measured by enzyme-linked immunosorbent assay(ELISA) in 62 patients with condyloma acuminatum and 35 conrols before and after treatment.Results Before treatment,the serum MIF and HMGB1 levels in the patients were significantly higher than those of controls(P<... |
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| Keywords: | Condyloma acuminatum Macrophage migration inhibitory factor(MIF) High mobility group box-1(HMGB1) |
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