| 急性药物性肝损伤129例临床分析 |
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| 引用本文： | 王胜炳,汪福群,曾安祥.急性药物性肝损伤129例临床分析[J].现代医院,2011,11(8):11-13. |
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| 作者姓名： | 王胜炳 汪福群 曾安祥 |
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| 作者单位： | 梅州市人民医院,广东梅州,514031 |
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| 摘 要： | 目的探讨急性药物性肝损伤临床表现特点、分型、病因、治疗及分析预后,以指导临床诊断和治疗。方法采用急性药物性肝损伤诊断及分类国内最新标准,回顾性分析近五年来129例急性药物性肝损伤住院患者的临床资料。结果本研究中有45.74%的患者无明显临床症状体征,其余亦缺乏特异性;有肝细胞型97例(75.19%),胆汁淤积型18例(13.95%),混合型14例(10.85%)。符合重症肝损伤者5例;很多药物可以引起肝功能损伤,本研究最常见的为抗结核药、中药、抗细菌药;86.05%患者预后较好,主要肝功能指标于30 d内恢复至正常上限两倍以内。5例发展为肝功能衰竭,预后差。结论急性药物性肝损伤无特异性症状,不能单纯根据症状确定诊断;本组患者急性药物性肝损伤的类型以肝细胞型为主;引起急性药物性肝损伤的药物种类很多,但以抗结核药、中药、抗细菌药发生率最高,临床应用此类药物时,应及时监测肝功能。在本组患者中急性药物性肝损伤大部分预后良好,但肝功能严重损害亦可发生,应及时发现并积极治疗。
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| 关 键 词： | 肝损伤 药物诱导 病因 预后 |
CLINICAL ANALYSIS OF 129 CASES OF ACUTE DRUG-INDUCED LIVER INJURY |
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| WANG Shengbing,WANG Fuqun,ZENG Anxiang.CLINICAL ANALYSIS OF 129 CASES OF ACUTE DRUG-INDUCED LIVER INJURY[J].Modern Hospital,2011,11(8):11-13. |
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| Authors: | WANG Shengbing WANG Fuqun ZENG Anxiang |
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| Institution: | WANG Shengbing,WANG Fuqun,ZENG Anxiang People's Hospital of Meizhou City,Guangdong Province514031 PRC |
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| Abstract: | Objective To investigate the clinical manifestation,classification,causative drugs,therapy and the prognosis of acute drug-induced liver injury to guide clinical diagnosis and therapy.Methods 129 inpatients with acute drug-induced liver injury in the past five years were retrospectively investigated with the causality assessment method of acute drug-induced liver diseases based on the latest domestic criteria.Results No obvious symptoms and signs are shown in 45.74% cases.In this study,97(75.19%),18(13.95%)... |
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| Keywords: | Liver injury Drug induced Diagnosis Etiology Prognosis |
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