2型糖尿病人群SNP＋45基因型与SNP和抵抗素的水平

目的探讨广州地区2型糖尿病人群与健康人群脂联素＋45（SNP＋45）位点不同基因型间TC、apoA1、apoB、RETN、APN、TG和Lp（a）水平变化及意义。方法采用病例-对照研究模式,分别测定广州地区已知脂联素＋45（SNP＋45）位点基因型的2型糖尿病人群和健康人群的TC、apoA1、apoB、RETN、APN、TG和Lp（a）,并进行统计分析。结果 2型糖尿病人群和健康人群SNP＋45位点的TT基因型组与相应的GG＋TG基因型组之间的TC、apoA1、apoB、RETN、APN、TG和Lp（a）比较异均无统计学意义。2型糖尿病人群SNP＋45位点TT基因型组与健康人群SNP＋45位点TT基因型组之间的apoB、RETN、TG差异有统计学意义。2型糖尿病人群SNP＋45位点GG＋TG基因型组与健康人群SNP＋45位点GG＋TG基因型组之间的TC、apoB、RETN、TG和Lp（a）有统计学意义上的差异。结论 2型糖尿病人群脂联素SNP＋45位点各基因型组的apoB、RETN、TG明显高于健康人群,显示脂联素SNP＋45基因型与2型糖尿病有关。

Correlation of adiponectin+45 nucleotide polymorphism genotype with adiponectin and resistin levels in type 2 diabetic patients and the healthy population in Guanghou

Aim To investigate the variations and significance of total cholesterol(TC)apolipoprotein,apolipoprotein A1 (apoA1),apolipoprotein B(apoB),resistin(RETN),adiponectin(APN)and triglyceride(TG)between type 2 diabetes and the healthy people with different genotypes of adiponectin +45 nucleotide polymorphism(SNP+45)in Guangzhou.Methods With a case-control study mode the levels of TC,apoA1,apoB,RETN,APN,TG and Lp(a)in type 2 diabetic patients and the healthy people were anlayzed.Results The levels of TC,apoA1,apo...