| 炔雌醇环丙孕酮联合螺内酯对多囊卵巢综合征患者激素的影响 |
| |
| 引用本文： | 黄伟祥,王小慧,麦敏,何青. 炔雌醇环丙孕酮联合螺内酯对多囊卵巢综合征患者激素的影响[J]. 现代医院, 2011, 11(7): 54-56. DOI: 10.3969/j.issn.1671-332X.2011.07.024 |
| |
| 作者姓名： | 黄伟祥 王小慧 麦敏 何青 |
| |
| 作者单位： | 1. 廉江市妇幼保健院,广东廉江,524400
2. 暨南大学第一临床医学院,广东广州,510632 |
| |
| 摘 要： | 目的观察炔雌醇环丙孕酮(达英-35)联合螺内酯治疗多囊卵巢综合征(PCOS)对患者激素及体液潴留的影响。方法 54例PCOS随机分为观察组及对照组各27例,对照组给予"氯米芬+促卵泡成熟素"促排卵+达英-35治疗,观察组在此基础上加用螺内酯;比较两组排卵妊娠情况、临床表现、激素代谢水平以及水液代谢情况。结果①观察组出现周期排卵、单卵泡发育及妊娠的例数显著多于对照组(p<0.05);②激素水平方面,治疗后观察组促黄体生成激素(LH)、LH/FSH、催乳素(PRL)及睾酮(T)显著低于对照组(p<0.05);③临床表现方面,治疗后观察组的多毛、痤疮评分以及体重指数(BMI)显著低于对照组;④治疗后观察组的尿量显著增多并明显多于对照组(p<0.05),且血钠显著低于对照组,但血钾均在正常范围内且无组间差异。结论加用螺内酯可增强达英-35改善PCOS患者激素代谢紊乱症状,从而促进排卵及妊娠,且螺内酯还有改善体液的作用。
|
| 关 键 词： | 多囊卵巢综合征 炔雌醇环丙孕酮 螺内酯 体液潴留 血钠 |
INFLUENCE OF SPIROLACTONE COMBINED WITH CYPROTERONE ACETATE ON SEX HORMONE OF PATIENTS WITH POLYCYSTIC OVARY SYNDROME |
| |
| HUANG Weixiang,WANG Xiaohui,MAI Min,et al Lianjiang Maternal , Child Health Care Hospital,Lianjiang City,Guangdong Province PRC. INFLUENCE OF SPIROLACTONE COMBINED WITH CYPROTERONE ACETATE ON SEX HORMONE OF PATIENTS WITH POLYCYSTIC OVARY SYNDROME[J]. Modern Hospital, 2011, 11(7): 54-56. DOI: 10.3969/j.issn.1671-332X.2011.07.024 |
| |
| Authors: | HUANG Weixiang WANG Xiaohui MAI Min et al Lianjiang Maternal Child Health Care Hospital Lianjiang City Guangdong Province PRC |
| |
| Affiliation: | HUANG Weixiang,WANG Xiaohui,MAI Min,et al Lianjiang Maternal and Child Health Care Hospital,Lianjiang City,Guangdong Province 524400 PRC |
| |
| Abstract: | Objective To evaluate the effect of spirolactone combined with cyproterone acetate(Diane-35)on sex hormone for patients with polycystic ovary syndrome(PCOS).Methods 54 PCOS patients were randomly divided into the observation and control group(both n=27).For the control group,a therapeutic schedule consisting of clomiphene citrate(CC),human menopausal gonadotropin(HMG)and Diane-35 was applied.Based on which,spirolactone was given to the observation group.The ovulation,pregnancy,level of sex hormone,clinical ... |
| |
| Keywords: | Polycystic ovary syndrome Cyproterone acetate Spirolactone Fluid retention Blood sodium |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
