轮状病毒肠炎伴良性婴幼儿惊厥39例临床分析

目的探讨轮状病毒肠炎伴良性婴幼儿惊厥的临床特点。方法回顾分析2004年10月~2009年12月本院轮状病毒肠炎伴良性婴幼儿惊厥患者的临床表现、实验室检查和治疗效果并进行随访。结果 39例患儿男23例,女16例,发病年龄4～26个月,病程3天内发生惊厥,呈全身强直-阵挛性发作,一次病程中发作1～4次,持续时间短,易控制。发作间期脑电图无明显异常,血生化、脑脊液及颅脑影像学检查正常。惊厥停止后未予抗癫痫治疗。随访3～66月,2例复发,病程〈1年。所有患儿预后良好,生长发育如正常儿童。结论轮状病毒肠炎伴良性婴幼儿惊厥多为良性过程,预后好,不必长期抗癫痫治疗,但须注意复发可能。

Clinical analysis of 39 rotavirus gastroenteritis cases with benign infantile convulsions

Aim To investigate the clinical features of rotavirus gastroenteritis cases with benign infantile convulsions.Methods There 39 hospitalized infant rotavirus gastroenteritis cases accompanied with benign afebrile seizures including 23 boys and 16 girls,aged 4～26 months old from October 2004 to December 2009 were observed.Results The convulsions were generalized tonic-clonic seizures,occurring between the first and the third day of gastroenteritis,1 to 4 times during a single episode and easy to be controlled with short duration.All displayed normal EEG background in interictal period.The serum biochemistry,cerebrospinal fluid and neuroimaging studies were performed with a normal results.No patient was put on long-term treatment with antiepileptic drugs.After 3～66 months follow-up,relapse occurred in 2 patients,with an episode less than 1 year.All showed a favorable prognosis.Conclusion Recognition of rotavirus gastroenteritis with benign infantile convulsions can avoids extensive evaluation and long-term antiepileptic therapy.Attention should be paid to recurrence.