| 替吉奥联合奥沙利铂治疗进展期胃癌安全性评价 |
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| 引用本文： | 董静波,李雁,翁国爱,殷晓玲,阮捷,郑军状. 替吉奥联合奥沙利铂治疗进展期胃癌安全性评价[J]. 肿瘤学杂志, 2011, 17(4): 253-256 |
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| 作者姓名： | 董静波 李雁 翁国爱 殷晓玲 阮捷 郑军状 |
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| 作者单位： | 1. 慈溪市中医医院,浙江,慈溪,315300
2. 上海市中医医院,上海,201203 |
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| 摘 要： | [目的]评价替吉奥联合奥沙利铂治疗进展期胃癌的临床疗效和安全性。[方法]采用随机对照法,将36例进展期胃癌患者随机分为替吉奥联合奥沙利铂组（18例）和FOLFOX4组（18例）,至少行2个周期化疗后评价疗效与不良反应。[结果]36例患者均可评价疗效,替吉奥联合奥沙利铂组CR1例（5.6%）,PR7例（38.9%）,SD6例（33.3%）,PD4例（22.2%）,有效率44.5%;FOLFOX4组PR6例（33.3%）,SD10例（55.5%）,PD2例（11.1%）,有效率33.3%;两组有效率比较差异无统计学意义（χ2=0.808,P=0.369）。两组主要不良反应为血液学毒性、胃肠道反应和神经系统毒性,其中FOLFOX4组恶心呕吐发生率显著高于替吉奥联合奥沙利铂组（χ2=4.485,P=0.034）。[结论]替吉奥联合奥沙利铂方案治疗进展期胃癌疗效与FOLFOX4方案相当,但耐受性较好。
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| 关 键 词： | 胃肿瘤 药物疗法 替吉奥 奥沙利铂 |
Safety Evaluation of TS-1 plus Oxaliplatin in the Treatment for Advanced Gastric Cancer |
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| DONG Jing-bo,LI Yan,WENG Guo-ai,et al.. Safety Evaluation of TS-1 plus Oxaliplatin in the Treatment for Advanced Gastric Cancer[J]. Journal of Chinese Oncology, 2011, 17(4): 253-256 |
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| Authors: | DONG Jing-bo LI Yan WENG Guo-ai et al. |
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| Affiliation: | DONG Jing-bo1,LI Yan2,WENG Guo-ai1,et al.(1.Cixi Hospital of Traditional Chinese Medicine,Cixi 315300,China,2.Shanghai Hospital of Traditional Chinese Medicine,Shanghai 201203,China) |
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| Abstract: | [Purpose] To evaluate the efficacy and safety of TS-1 plus oxaliplatin in the treatment of patients with advanced gastric cancer.[Methods]Thirty-six cases with advanced gastric cancer were randomly divided into TS-1 plus oxaliplatin group (n=18) and FOLFOX4 group (n=18).The efficacy and toxicity were evaluated after at least two cycles of chemotherapy.[Results] Response was evaluable in all patients.Of 18 cases in TS-1 plus oxaliplatin group,1 case in CR(5.6%),7 cases in PR(38.9%),6 cases in SD (33.3%) and ... |
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| Keywords: | gastric neoplasms drug therapy TS-1 oxaliplatin |
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