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| miR-221和miR-222在胃癌中的表达及临床意义 | |
| 引用本文： | 金晶,闫竞一,薛向阳,武文一,黄颖鹏,朱冠保,沈贤.miR-221和miR-222在胃癌中的表达及临床意义[J].肿瘤学杂志,2011,17(4):245-248. |
| 作者姓名： | 金晶 闫竞一 薛向阳 武文一 黄颖鹏 朱冠保 沈贤 |
| 作者单位： | 1. 温州医学院生命科学学院,浙江,温州,325035 2. 温州医学院附属第一医院,浙江,温州,325000 3. 温州医学院微生物与免疫教研室,浙江,温州,325035 |
| 基金项目： | 浙江省自然科学基金，温州市科技计划项目 |
| 摘 要： | 目的]探讨miR-221和miR-222在胃癌中的表达及与临床病理特征的关系。方法]应用茎环RT-PCR方法检测32例胃癌及癌旁胃黏膜组织中miR-221和miR-222表达,分析miR-221和miR-222表达与胃癌临床病理指标的关系。结果]胃癌组织miR-221和miR-222表达明显高于对应的正常胃黏膜组织（P〈0.05）,且胃癌与正常胃黏膜组织中miR-221和miR-222比值也有显著性差异（P=0.05）。miR-222表达与胃癌分化程度相关（P=0.046）;miR-221表达与淋巴结转移相关（P=0.013）。结论]miR-221和miR-222在胃癌中表达明显上调是胃癌的重要标志,但两者在胃癌发生发展的不同阶段,可能发挥不同的效应。 |
| 关 键 词： | miR-221 miR-222 胃肿瘤 |
Expression of miR-221 and miR-222 in Gastric Cancer and its Clinical Significance |
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| JIN Jing,YAN Jing-yi,XUE Xiang-yang,et al..Expression of miR-221 and miR-222 in Gastric Cancer and its Clinical Significance[J].Journal of Oncology,2011,17(4):245-248. | |
| Authors: | JIN Jing YAN Jing-yi XUE Xiang-yang |
| Institution: | JIN Jing1,YAN Jing-yi2,XUE Xiang-yang3,et al.(1.School of Life Sciences,Wenzhou Medical College,Wenzhou 325035,China,2.The First Affilia-ted Hospital of Wenzhou Medical College,Wenzhou 325000,3.Department of Microbiology,China) |
| Abstract: | Purpose] To investigate the expression of miR-221 and miR-222 in gastric cancer and its relationship with clinicopathologic features.Method] The expression of miR-221 and miR-222 in 32 cases of gastric cancer tissues and their matched non-tumor adjacent tissues was examined by stem-loop RT-PCR.And the correlation with clinicopathologic features was investigated.Results] The expression of miR-221 and miR-222 in gastric cancer tissues was significantly higher than those in adjacent tissues(P<0.05).The rati... |
| Keywords: | miR-221 miR-222 |
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