| 南沙参多糖改善东莨菪碱所致大鼠学习记忆障碍的研究 |
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| 引用本文： | 张春梅,李新芳. 南沙参多糖改善东莨菪碱所致大鼠学习记忆障碍的研究[J]. 中药药理与临床, 2001, 17(6): 19-21 |
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| 作者姓名： | 张春梅 李新芳 |
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| 作者单位： | 1. 甘肃省医学科学研究所,兰州,730050
2. 兰州医学院,兰州,730000 |
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| 摘 要： | 目的：探讨南沙参多糖（RAPS）对东莨菪碱所致大鼠学习记忆障碍的影响。方法：igRAPS500－2000mg/kg每天一次共15天，大鼠穿梭箱法测定学习记忆能力，化学荧光法测定单胺类递质的含量。结果：大鼠主动回避反应率显增加；大鼠脑中NE、DA、5－HT含量增加，AchE活性降低；血糖含量增加。结论：RAPS具有改善大鼠学习记忆的功能，其作用与影响鼠脑中神经递质及血糖有关。
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| 关 键 词： | 南沙参多糖 东莨菪碱 学习记忆障碍 |
Improving effect of Radix Adenophorae Potanini Korsh Polysaccharides (RAPS) on scopolamine-induced impairment of learning and memory in rats |
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| Zhang Chunmei,Li Xinfang. Improving effect of Radix Adenophorae Potanini Korsh Polysaccharides (RAPS) on scopolamine-induced impairment of learning and memory in rats[J]. Pharmacology and Clinics of Chinese Materia Medica, 2001, 17(6): 19-21 |
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| Authors: | Zhang Chunmei Li Xinfang |
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| Affiliation: | Zhang Chunmei,Li Xinfang 1 |
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| Abstract: | RAPS potently improves the impairment of learning and memory in rats induced by scopolamine, the rate of active avoidance response was raised significantly. RAPS attenuated reductions of content of NE, DA and 5 HT in rats' brains and g lucose in rats' blood produced by scopolamine. RAPS inhibited AchE activity in r ats' brains. |
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| Keywords: | Radix Adenophorae learning and memo ry scopolamine active avoidance response |
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