Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades |
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| Authors: | Cheng-shi Jiang Lin-fu Liang Yue-wei Guo |
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| Affiliation: | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented. |
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| Keywords: | natural products phytochemistry protein tyrosine phosphatase 1B (PTP1B) inhibitor structure-activity relationship (SAR) type 2 diabetes obesity |
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