Anti-Diabetic Activities of the Methanol Leaf Extracts of Hymenocardia Acida (Tul.) in Alloxan-Induced Diabetic Rats |
| |
| Authors: | Ihechiluru I Ezeigbo Isaac U Asuzu |
| |
| Affiliation: | 1.Department of Veterinary Physiology, Biochemistry and Pharmacology, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria;2.Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Enugu State, Nigeria |
| |
| Abstract: | The effect of methanolic extract of Hymenocardia acida leaves on diabetes and associated lipidemia were investigated on experimentally-induced diabetic rats. The extract did not demonstrate any acutely toxic effect in rats within the dose range (250 mg/kg – 2000 mg/kg) employed in the study; hence it was well tolerated by the rats. In all experiments, the anti-diabetic effects were dose-dependent and comparable to that of glibenclamide (2 mg/kg) standard. At a dose of 500 mg/kg, lipid profile markers such as the serum total cholesterol (TC) levels, LDL-C, triglycerides and HDL-C were significantly lower (p <0.05) than those of both the treated and untreated controls. |
| |
| Keywords: | Hymenocardia acida Diabetes mellitus Lipid profile Glibenclamide Alloxan monohydrate |
|
|
