|
|||||
|
|
SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease |
||
| Authors: | John Wityak Michael E Prime Frederick&#;A Brookfield Stephen M Courtney Sayeh Erfan Siw Johnsen Peter D Johnson Marie Li Richard W Marston Laura Reed Darshan Vaidya Sabine Schaertl Anna Pedret-Dunn Maria Beconi Douglas Macdonald Ignacio Mu?oz-Sanjuan Celia Dominguez | |
| Institution: | †CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States;‡Evotec (U.K.) Ltd., 114 Milton Park, Abingdon, OX14 4SA, United Kingdom;§Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany | |
| Abstract: | ||
| Keywords: | plasma stability polar surface area acrylamides celiac disease in vitro ADME | |