Novel Carboxamide-Based
Allosteric MEK Inhibitors:
Discovery and Optimization Efforts toward XL518 (GDC-0973) |
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| Authors: | Kenneth D. Rice,Naing Aay,Neel K. Anand,Charles M. Blazey,Owen J. Bowles,Joerg Bussenius,Simona Costanzo,Jeffry K. Curtis,Steven C. Defina,Larisa Dubenko,Stefan Engst,Anagha A. Joshi,Abigail R. Kennedy,Angie I. Kim,Elena S. Koltun,Julie
C. Lougheed,Jean-Claire L. Manalo,Jean-Francois Martini,John M. Nuss,Csaba J. Peto,Tsze H. Tsang,Peiwen Yu,Stuart Johnston |
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| Affiliation: | Exelixis Inc., 210 East Grand Avenue, South San Francisco, California 94080, United States |
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| Abstract: | | |
| Keywords: | MAPK pathway MEK cancer kinaseinhibitor XL518 GDC-0973 |
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