IL-23 Gene Expression in PBMCs of Patients with Coronary Artery Disease |
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| Authors: | Maryam Khojasteh-Fard Milad Abolhalaj Parvin Amiri Majid Zaki Zahra Taheri Mostafa Qorbani Javad Tavakkoly Bazzaz Mahsa M Amoli |
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| Institution: | 1.Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran;2.Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;3.Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | Objective: Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. Methods: Expression profiles of IL-17, IL-23, and TGF-β1 were determined in individuals with and without CAD using Real-time PCR. Results: A significant decrease in IL-23 gene expression in un-stimulated PBMCs of patients with CAD compared to those without CAD was found (p=0.003, OR=0.045, 95% CI: 0.006–0.355). Conclusion: Our data reinforce the potential role of the IL-23 as a critical regulatory molecule that bridges the innate and adaptive arms of the immune system in the complex mechanisms associated with the development of atherosclerosis. |
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| Keywords: | Cytokine gene expression CAD IL-23 |
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