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Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo |
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| Authors: | Vincent Gasparik Fran?ois Daubeuf Muriel Hachet-Haas Fran?ois Rohmer Patrick Gizzi Jacques Haiech Jean-Luc Galzi Marcel Hibert Dominique Bonnet Nelly Frossard |
| Affiliation: | †Laboratoire d''Innovation Thérapeutique, UMR 7200 CNRS/Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, 67401 Illkirch, France;‡Biotechnologie et signalisation cellulaire, UMR 7242 CNRS/Université de Strasbourg, ESBS, Bld Sébastien Brant, 67412 Illkirch, France |
| Abstract: | l-seryl, and sulfate, all inactive by themselves on CXCL12 butwhen cleaved in vivo into 1, highly active locally ata low dose in a mouse airway hypereosinophilia model. |
| Keywords: | prodrug solubility CXCL12 chemokine CXCR4 receptor GPCR asthma |