Dependence Potential of Propofol: Behavioral Pharmacology in Rodents |
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Authors: | Hye Jin Cha Ji-Hun Cha Hea-Young Cho Eun-Yong Chung Kyoung-Jin Kwon Jun Yeon Lee Ho-Sang Jeong Hye-Soo Kim Hye-Joo Chung Eun Jung Kim |
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Institution: | 1.National Institute of Food and Drug Safety Evaluation;2.Korea Food and Drug Administration, Cheongwon 363-951;3.Department of Physiology, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea |
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Abstract: | Propofol is an anesthetic commonly used to provide sedation or to induce and maintain an anesthetic stated. However, there are reports which indicate propofol may cause psychological dependence or be abused. In the present study, we used various behavioral tests including climbing test, jumping test, conditioned place preference, and self-administration test to assess the dependence potential and abuse liability of propofol compared to a positive control (methamphetamine) or a negative control (saline or intralipid). Among the tests, the conditioned place preference test was conducted with a biased method, and the selfadministration test was performed under a fixed ratio (FR) 1 schedule, 1 h per session. No difference was found in the climbing test and jumping test, but propofol (30 mg/kg, i.p.) increased the rewarding effect in the conditioned place preference test, and it showed a positive reinforcing effect compared to the vehicle. These results indicate that propofol tends to show psychological dependence rather than physical dependence, and it seems not to be related with dopaminergic system. |
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Keywords: | Propofol Psychological dependence Physical dependence Animal behavioral test |
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