多发性肌炎/皮肌炎病因和发病机制研究进展

 多发性肌炎（polymyositis，PM）和皮肌炎（dermatomyositis，DM）是累及全身骨骼肌为主的慢性炎症性肌病，其确切发病机制未明。随着对该病研究的不断深入和新的研究技术的使用，近年来人们对该病发病机制的认识不断加深，大都认为本病与自身免疫异常有关，非免疫机制亦有所研究。但目前国内外尚无全面描述这些进展的相关综述，本文就该病发病机制的研究进展做一综述，并将各种机制假说有机联系起来以使人们更加深刻地认识该病。

Advancement in the study of pathogenesis of polymyositis/dermatomyositis

Polymyositis (PM) and dermatomyositis (DM) are inflammatory myopathies and slowly advanced of unknown etiology that affect the skeletal muscles.With the advancement of the constant research on the disease and use of new technology,people have a penetrating realization about the pathogenesis. The disease is thought to be associated with autoimmune as well as nonimmune mechanism. By now, there is no overall summary on the newest advancement of the pathogenesis.We summarized the progress on the pathogenesis of the disease in order to make it more clear to physicians.