Synthesis and anticholinesterase activity and cytotoxicity of novel amide derivatives |
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Authors: | Altintop Mehlika Dilek Kaplancikli Zafer Asim Ozdemir Ahmet Turan-Zitouni Gülhan Temel Halide Edip Akalın Gülşen |
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Affiliation: | 1. Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eski?ehir, Turkey;2. Anadolu University, Faculty of Pharmacy, Department of Biochemistry, Eski?ehir, Turkey |
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Abstract: | In the present study, some amide derivatives were synthesized and their potential anticholinesterase properties were investigated. N-(Benzothiazol-2-yl)-2-[(5-amino/methyl-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives were obtained by nucleophilic substitution of 2-chloro-N-(benzothiazole-2-yl)acetamide derivatives with appropriate 1,3,4-thiadiazole-2-thioles. The chemical structures of the compounds were elucidated by (1) H-NMR, (13) C-NMR and FAB(+) -MS spectral data and elemental analyses. Each amide derivative was evaluated for its ability to inhibit AChE and BuChE using a modification of Ellman's spectrophotometric method. The compounds were also investigated for their cytotoxic properties using MTT assay. 2-(5-Amino-1,3,4-thiadiazol-2-yl)thio-N-(benzothiazol-2-yl)acetamide derivatives have anticholinesterase activity, whereas 2-(5-methyl-1,3,4-thiadiazol-2-yl)thio-N-(benzothiazol-2-yl)acetamide derivatives have no inhibitory effect on enzyme activity. Among these compounds, it is clear that compound IIh is the most potent derivative. |
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Keywords: | Amide Anticholinesterase activity Cytotoxicity Thiadiazole |
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