RTVue OCT在正常人和青光眼视神经纤维层厚度和视盘参数测量的中重复性研究

目的: 研究RTVue 频域OCT 在正常人和青光眼中的视神经纤维层厚度和视盘参数测量中的重复性。 方法: 临床观察性研究。89名正常人和63名不同程度的青光眼患者入组，随机选择一眼连续3次测量视神经纤维层厚度和视盘参数。所有测量均由同一操作者完成。通过计算标准差、精确度、变异系数、和组内相关系数（ICC）来评价备的重复性。 结果: 神经纤维层厚度呈现双峰型。所有的视盘参数和均有良好的重复性。对于正常人，ICC介于0.98至1。对于不同程度的青光眼，则介于0.94至1。神经纤维层厚测量也显现良好的重复性，所有受检者的ICC值为0.95至1。对于不同区域的神经纤维层厚度测量，正常人ICC为0.94至0.98，轻度的青光眼患者则为0.94至1，中度0.87至1，重度0.77至0.97，其中重度青光眼的鼻侧变异最大，鼻下和鼻侧分别为0.77和0.87。 结论: RTVue OCT 在正常人和青光眼中的视神经纤维层厚度和视盘参数测量的中有良好的重复性。

Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Nerve Head Measurements in Normal and Glaucoma Eyes

Purpose: To evaluate reproducibility of RTVue spectral-domain optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) measurements in normal and glaucoma eyes. Methods: This study was an observational clinical study. One eye was selected randomly from each of 89 normal individuals and 63 glaucoma patients in a range of severity. RNFL thickness and ONH were measured 3 times on the same day to determine intrasession variability. The same instrument was used by the same operator for all scans. Intrasession within-subject standard deviation ( SW ), precision ( 1.96×SW ), coefficient of variation ( CVw ) ( 100×SW / overall mean ), and intraclass coefficient ( ICC ) were calculated to evaluate reproducibility. Results: RTVue OCT demonstrated double hump patterns in the RNFL profiles. High reproducibility was observed in all ONH parameters. For normal eyes, the value of ICC ranged between 0.98 and 1. For eyes with different extent of glaucoma, it ranged between 0.94 and 1. High reproducibility was also observed in RNFL thickness measurements. The values of ICC for averaged RNFL thickness ranged between 0.95 and 1 in all cases. For regional parameters, it ranged from 0.94 to 0.98 for normal eyes, 0.94 to 1 for mild glaucoma eyes, 0.87 to 1 for moderate glaucoma eyes, and 0.77 to 0.97 for severe glaucoma eyes. The nasal regions of severe glaucoma appeared to be most variable, as NL and IN had the ICC values of 0.77 and 0.87. Conclusions: Reproducibility of RTVue RNFL and ONH measurements was excellent in normal and glaucoma groups.