Plant cell cultures as a source of bioactive small molecules |
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Authors: | Stafford Angela M |
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Affiliation: | Phytera Ltd, Regent Court, Regent Street, Sheffield, S1 4DA, UK. a.m.stafford@sheffield.ac.uk |
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Abstract: | Plants have provided some of our most important pharmaceuticals and are a continuing source of novel bioactive molecules for drug development. Cell suspension cultures of higher plants are a complementary source of novel chemistry with significant advantages over whole plants, including plasticity of expression and re-accessibility. With an emphasis on recent progress, the use of plant cell cultures for both new lead discovery and as a route to the production of known bioactives will be described. Developments in strategies that can be applied to facilitate future success in the area are discussed. |
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