The genus Bifidobacterium for cancer gene therapy |
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Authors: | Fujimori Minoru Amano Jun Taniguchi Shun'ichiro |
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Institution: | Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. minoru1@hsp.md.shinshu-u.ac.jp |
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Abstract: | A fundamental obstacle in cancer gene therapy is the specific targeting of therapy to solid tumor; as yet, no systemic delivery system exists. Bifidobacterium longum, a strain of domestic bacteria that is non-pathogenic and anaerobic, selectively localized to and proliferated in solid tumors after systemic application. We propose a novel approach to cancer gene therapy in which anaerobic bacteria of the genus B longum are used to achieve tumor-specific gene delivery and enzyme-prodrug therapy. |
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