肝硬化患者心功能的临床研究

目的　研究肝硬化患者心脏功能及肝功能损害程度、病程、门静脉压力、腹水量对肝硬化患者心脏功能的影响。方法　选取肝硬化 3 0例 (研究组 ) ,慢性肝炎 10例 (对照组 ) ,进行肝功能、腹部B超、核素心肝血流比、彩色多普勒超声心脏检查。结果　肝硬化患者E/A值较慢性肝炎患者降低 ,两者差异有显著性 (P <0 .0 5)。ChildA级和ChildB级肝硬化患者E/A值差异无显著性 (P >0 .0 5) ,ChildC级肝硬化患者E/A值与ChildA级和ChildB级肝硬化患者E/A值差异均有显著性 (P <0 .0 5)。病程 10年以上肝硬化患者E/A值与病程 10年以内肝硬化患者E/A值比较 ,差异有显著性 (P <0 .0 5)。门静脉压力 40cmH2 O以上肝硬化患者E/A值与门静脉压力 40cmH2 O以下肝硬化患者E/A比较 ,差异均有显著性 (P <0 .0 5)。无腹水、少量腹水、大量腹水的肝硬患者E/A值差异无显著性 (P >0 .0 5)。结论　肝硬化患者心脏舒张功能减低 ,其与肝功能损害程度、病程、门静脉压力有关 ,与腹水量无明显相关性。

The study on cardiac function of liver cirrhosis patients

ObjectiveTo study cardiac function of liv er cirrhosis patients and the relationships between cardiac function and liver func tion,histories,portal pressure,ascites volume.MethodsA total of 30 liver cirrhosis patients (study group) an d 10 c hronic hepatitis patients(control group) were examined by Doppler echocardiogra phy,liver function test,abdominal ultrosonography and H/L.ResultsThere was a significant difference between the E/A of liv er cirr hosis patients and that of chronic hepatitis patients;there wasn't a significant difference between the E/A of Child A liver cirrhosis patients and that of Child B liver cir rhosis patients.There was a significant difference between the E/A of Child C li ver cir rhosis patients and that of Child A and Child B liver cirrhosis patients.There w as a si gnificant difference between the E/A of portal pressure above 40 cmH 2O liver c irrhos is patients and that of below 40 cmH 2O liver cirrhosis patients.There is a sig nifica nt difference between the E/A of above 10 years liver cirrhosis patients and tha t of bel ow 10 years liver cirrhosis patients;there were no significant differences among the E /A of no ascites,little volume ascites and large volume ascites liver cirrhosis patients.ConclusionThe cardiac dilastolic function of liver cirrhosis patients obviously decrease( P <0.05).There are positi ve relations between the cardiac dilastolic function of liver cirrhosis patients and li v er function,histories,portal pressure.There aret's relations between the cardiac dilastolic function and ascites volume of liver cirrhosis patients.