Acute and late genitourinary toxicity of conformal radiotherapy for prostate cancer |
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Authors: | Yoshimura Ryo-ichi Iwata Masaru Shibuya Hitoshi Sakai Yasuyuki Kihara Kazunori |
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Institution: | (1) Department of Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan;(2) Department of Urology, Tokyo Medical and Dental University, Tokyo, Japan |
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Abstract: | Purpose The aim of this study was to identify predictive factors for genitourinary (GU) toxicity in prostate cancer patients who underwent
conformal radiotherapy (CRT).
Materials and methods In this study we analyzed 154 cases of T1-3N0M0 prostate adenocarcinoma and evaluated the occurrence rate of acute and late
GU toxicity and the duration of acute toxicity according to clinical parameters: age, transurethral resection of the prostate
prior to CRT, hormone therapy, CRT dose, length of planning target volume (PTV).
Results Altogether, 41% of the patients developed grade 2 or higher acute GU toxicity. Longer PTV was significantly associated with
a higher incidence of acute GU toxicity (>7 cm, 53%; ≤7 cm, 31%; P = 0.003), and hormone therapy prolonged the duration of the toxicity (P = 0.007). Grade 1 or higher late GU toxicity developed in 23% of the patients, and the 2-year late GU toxicity-free survival
rate was 79%. Acute GU toxicity was significantly associated with the late GU toxicity-free survival rate (grade 0–1, 88.7%;
grade 2–4, 73.2%; P = 0.0007).
Conclusion The length of PTV and hormone therapy were predictive factors for acute GU toxicity. Furthermore, acute GU toxicity was the
most important predictive factor for late GU toxicity. |
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Keywords: | Prostate cancer Conformal radiotherapy Genitourinary (GU) toxicity |
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