丙基硫氧嘧啶治疗妊娠合并甲状腺功能亢进54例临床疗效观察

目的探讨丙基硫氧嘧啶治疗妊娠合并甲状腺功能亢进的疗效。方法将108例妊娠合并甲状腺功能亢进的患者平均分为丙基硫氧嘧啶（PTU）组和甲巯咪唑（MMI）组。前者采用PTU，后者采用MMI进行诊治。定期检查两组患者甲状腺功能，测定血清中促甲状腺激素（TSH）、血清游离甲状腺激素（FT4）和血清游离三碘甲腺原氨酸（FT3）的含量，根据监测结果调整药物剂量。结果治疗后，丙基硫氧嘧啶组孕妇的血清FT4和FT3含量比甲巯咪唑组低，且并发症发生率低于甲巯咪唑组，差异具有统计学意义沪〈0．05）。结论门u是目前临床上治疗妊娠期甲状腺功能亢进的首选药物，能够有效缓解甲状腺功能亢进症状，控制病情的发展，不会对孕妇和胎儿造成不良影响，值得在临床上推广应用。

Propylthiouracil for pregnancy complicate by hyperthyroidism in 54 women

Objective To explore the efficacy of propyhhiouracil in the treatment of pregnancy complicated by hyperthyroidism. Methods 108 pregnant women with hyperthyroidism were evenly assigned to receive propylthiouraeil （PTU group）, or methimazole （MMI group）. Levels of serum TSH, FT4 and FT3 were detected regularly. The dosage of anti-thyroid agents was adjusted according to the test results. Results Levels of serrum FT4 and FTB were lower in PTU group than in MMI group and the rate of complications was lower in PTU group, with significant statistical differences （P〈0.05）. Conclusions Propylthiouracil is the first choice in the treatment of pregnancy complicated by hyperthyroidism. It can effectively relieve symptoms of hyperthyroidism and control the development of the disease and has no adverse effects on pregnant women and fetuses. It is worth popularizing clinically.