一次性输注泵持续输注氟尿嘧啶的效果观察

目的探讨应用一次性输注泵持续输注氟尿嘧啶对用药速度与时间以及剂量控制的影响，并观察患者的化疗效果及毒副反应。方法将100例妇科恶性肿瘤患者随机分为对照组50例和观察组50例。对照组采用传统的静脉短期滴注方法输注氟尿嘧啶，观察组采用一次性输注泵持续输注氟尿嘧啶44～48h。结果观察组患者能够顺利完成全程化疗治疗显著高于对照组，毒副反应发生率显著低于对照组（P〈0．05）。结论采用一次性输注泵在妇科恶性肿瘤患者化疗治疗过程中安全有效，降低了氟尿嘧啶毒副反应的发生率，提高患者生活质量，保证患者能够顺利完成全程化疗治疗，疗效显著。

Effect of a disposable infusion pump used for continuous infusion of fluorouracil

Objective To explore the effect of a disposable infusion pump used for continuous infusion of fluorouracil on infusion speed and duration and dosage control, and to observe the efficacy and toxicity and adverse reactions of chemotherapy. Methods 100 patients with malignant gynecologic tumors were randomly divided into a control group and a study group, 50 for each group. The control group received traditional intravenous infusions of fluorouracil in a short time, while the study group received continuous infusions of fluorouracil for 44 to 48 h with a disposable infusion pump. Results The rate of patients who were able to complete a full course of chemotherapy successfully was significantly higher in the study group than in the control group; the rate of toxicity and adverse reactions was significantly lower in the study group than in the control group （P〈0.05）. Conclusions A disposable infusion pump is safe and effective during chemotherapy for patients with malignant gynecologic tumors. It reduces the incidence rate of toxicity and adverse reactions in chemotherapy with fluorouracil, improve quality of life, and ensure the completion of a full course of chemotherapy.