胃肠道间质瘤196例临床分析

目的 探讨胃肠道间质瘤的诊断和治疗方法.方法 回顾性分析我院2001年11月～2006年10月收治的胃肠道间质瘤196例的临床资料.本组病人均行手术治疗.结果 免疫组织化学项目CD117、CD34、SMA、S-100、Desmin的阳性率分别为100%、54.6%、52.6%、15.3%、0.术后死于初次复发7例,死于再次手术后3例.本组5年生存率为94.8%.接受格列卫治疗者共38例,完全缓解3例,部分缓解31例,疾病稳定4例.结论 组织形态及免疫组织化学染色是诊断GIST的必要手段.加强对胃肠道间质瘤的认识,规范手术及合理的靶向药物治疗是GIST治疗的关键.

Clinical analysis of 196 cases of gastrointestinal stromal tumors

Objective To explore the clinical diagnosis and treatment of gastrointestinal stromal tumors(GIST).Methods The clinical data of 196 cases of GIST from Nov. 2001 to Oct. 2006 were analyzed retrospectively.All these patients were treated by surgery.Results Immunohistochemistry staining revealed that the positive rate of CD117,CD34,SMA,S-100 and Desmin was 100%,54.6%,52.6%,15.3% and 0 respectively.193 cases were followed up to date,in which 7 cases died of relapse after first surgery and 3 cases after second-time surgery,and the 5-year survival rate was 94.8%.There were totally 38 cases under the treatment of Gleevec,in which 3 cases obtained complete response,31 cases partially response and 4 stable disease.Conclusion Pathological and immunohistochemical staining technology are both necessary to diagnose GIST.Intensified understanding of GIST,regulated surgery and appropriate targeted treatment play significant roles in treatment of GIST.