| 当归中新的二聚苯酞衍生物 |
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| 引用本文： | 苏东敏,庾石山,秦海林. 当归中新的二聚苯酞衍生物[J]. 药学学报, 2005, 40(2): 141-144 |
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| 作者姓名： | 苏东敏 庾石山 秦海林 |
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| 作者单位： | 中国医学科学院、中国协和医科大学,药物研究所,北京100050 |
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| 基金项目： | 国家中医药管理局中医药科学技术研究专项资助项目(02 03ZP09). |
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| 摘 要： | 目的深入研究中药当归Angelica sinensis的化学成分。方法用硅胶柱色谱法和光谱分析法分离和鉴定化学成分。结果除3个已知的苯酞类结构外，从当归中又分离到1个新的二聚苯酞衍生物和一对几何异构体，经光谱分析鉴定其结构分别为Z-3′,8′,3′a,7′a-四氢-6,3′,7,7′a–二聚藁本内酯-8′-酮(1)、Z,Z′-6,6′,7,3′a-二聚藁本内酯(2)和2的8位几何异构体(3)。结论化合物1为新的二聚苯酞类衍生物，3为首次从当归中鉴定的二聚苯酞类衍生物。
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| 关 键 词： | 当归 Z-3′,8′,3′a,7′a-四氢-6,3′,7,7′a–二聚藁本内酯-8′-酮 E,Z′-6,6′,7,3′a-二聚藁本内酯 |
| 收稿时间： | 2004-04-23 |
New dimeric phthalide derivative from Angelica sinensis |
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| SU Dong-min,YU Shi-shan,QIN Hai-lin. New dimeric phthalide derivative from Angelica sinensis[J]. Acta pharmaceutica Sinica, 2005, 40(2): 141-144 |
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| Authors: | SU Dong-min YU Shi-shan QIN Hai-lin |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. |
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| Abstract: | AIM: To study the chemical constituents of the roots of Angelica sinensis. METHODS: Silica gel column chromatography was used to separate the chemical constituents. Their structures were elucidated by chemical and spectral analysis (IR, MS, 1D and 2D NMR, etc.). RESULTS: Besides three known phthalide derivatives, one new dimeric phthalide derivative and a pair of epimer were isolated and their structures were identified as Z-3',8',3'a,7'a-tetrahydro-6,3',7,7'a-diligustilide-8'-one (1), Z,Z'-6,6',7,3'a-diligustilide (2) and the 8-epimer (3) of 2 on the basis of spectral data. CONCLUSION: Compound 1 is a new dimeric phthalide derivative, and compound 3 was first reported from radix Angelica |
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| Keywords: | Z-3′,8′,3′a,7′a-tetrahydro-6,3′,7,7′a-diligustilide-8′-one E,Z′-6,6′,7,3′a-diligustilide Angelica sinensis |
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