葛根素及其磷脂复合物的体外透皮实验研究

目的 :考察葛根素及其磷脂复合物的体外透皮渗透情况 ,比较二者透皮速率与累积渗透量的差异。方法 :通过改进Franz扩散池进行小鼠体外皮肤渗透实验。结果 :葛根素磷脂复合物 1h内累积渗透量大于葛根素 ,以后其增加渐缓 ,而葛根素的渗透速率大于复合物。结论 :葛根素磷脂复合物经皮渗透能在短时间内较快地达到一定药量 ,随后缓慢持久地释放药物。

Studies Permeation of Puerarin and Its Phospholipid Complex through Rat Skin in Vitro

Objective: To investigate the skin permeation of puerarin and its phospholipid complex and compare the differences between their permeation rates and cumulative permeation amounts. Method: Performing a test of permeation through the rat skin in vitro in an improved Franz diffusion cell.Result: The cumulative permeation amount of phospholipid complex was higher than that of puerarin in the first hour and then increased slowly,meanwhile the permeation rate of puerarin rose higher than that of the complex.Conclusion:Phospholipid complex of puerarin can permeate through the rat skin rapidly up to a certain amount in a short time, then begins to release drug slowly and lastingly.