| PSA与fPSA联合诊断前列腺疾病的临床研究 |
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| 引用本文： | 熊江,陈忠,钱晓煜,季鸿,杨苏,丁颖,朱瑞森. PSA与fPSA联合诊断前列腺疾病的临床研究[J]. 标记免疫分析与临床, 2003, 10(1): 7-9 |
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| 作者姓名： | 熊江 陈忠 钱晓煜 季鸿 杨苏 丁颖 朱瑞森 |
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| 作者单位： | 上海市第六人民医院,核医学科,上海200233;上海市第六人民医院,泌尿外科,上海200233 |
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| 摘 要： | 评价前列腺特异抗原（PSA）和游离前列腺特异抗原（fPSA)的联合检测在前列腺疾病鉴别诊断中的价值。采用化学发光免疫分析法（CLIA）对前列腺癌患者32例、前列腺增生症患者76例及30名正常人的PSA、fPSA和fPSA/PSA比值进行了检测和分析。结果表明，如果以血清PSA值4ng/mL为阈值，诊断前列腺癌的灵敏度为100％，特异性为50．6％；如果以血清PSA值4ng/mL为阈值，同时结合fPSA/PSA并以16％为阈值，诊断前列腺癌的灵敏度为100％，而特异性则为85．3％。这说明联合检测对提高前列腺癌诊断的特异性有一定的价值。
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| 关 键 词： | 前列腺特异抗原 前列腺癌 前列腺增生症 化学发光免疫分析法 |
| 文章编号： | 1006-1703(2003)01-0007-03 |
| 修稿时间： | 2002-03-06 |
The Clinical Study of Serum PSA and fPSA Assayed By CLIA in Diagnosing Prostate Disease |
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| XIONG Jiang ,CHEN Zhong ,QIAN Xiao-yu ,et al.. The Clinical Study of Serum PSA and fPSA Assayed By CLIA in Diagnosing Prostate Disease[J]. Labeled Immunoassays and Clinical Medicine, 2003, 10(1): 7-9 |
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| Authors: | XIONG Jiang CHEN Zhong QIAN Xiao-yu et al. |
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| Affiliation: | XIONG Jiang 1,CHEN Zhong 2,QIAN Xiao-yu 1,et al. |
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| Abstract: | The purpose of this study is to evaluate the clinical value of PSA(prostate specific antigen) and fPSA(free prostate specific antigen)in differentiating prostate disease. CLIA was used to quantitatively assay PSA, fPSA and fPSA/PSA in 30 cases of normal controls, 32 cases of prostate cancer patients and 76 cases of BPH patients. The result showed that if liminal value of PSA was set at 4ng/mL, the diagnotic sensitivity and specificity of prostate cancer were 100% and 50.6% respectively. Meanwhile, if liminal value of fPSA/TPSA set at 16% was added, the diagnotic sensitivity and specificity of prostate cancer were 100%and 85.3%respectively. It was concluded that the combining assay of PSA and fPSA could increase the diagnotic specificity of prostate cancer in a certain degree. |
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| Keywords: | Prostate specific antigen Prostate cancer Prostate hyperplasia Chemiluminescence immunoassay |
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