四氧化二氮对大鼠图形视觉诱发电位的影响

目的:研究大鼠在航天推进剂四氧化二氮染毒后的图形视觉诱发电位改变。方法:正常雄性Winstar大鼠分3组,每组6~10只,其中一组用7.5mg、一组用15mg的四氧化二氮溶液进行ip染毒,一组为正常对照,每组均在晚上固定的时间进行图形视觉诱发电位检查。用SPSS10.0统计软件对数据进行分析。结果:正常大鼠与染毒大鼠之间及两组染毒大鼠之间的图形视觉诱发电位p100波的潜伏期的差异无统计学意义;正常大鼠与染毒大鼠之间及两组染毒大鼠之间的图形视觉诱发电位p100波的波幅值的差异亦无统计学意义。结论:四氧化二氮染毒对大鼠图形视觉诱发电位p100波具有一定程度的影响,表现为潜伏期稍延长,波幅值在剂量低时稍升高,剂量高时则降低,而且它们的变异多加大,其影响与染毒剂量有关,剂量大者,其变异更明显。但是其差异均无统计学意义。

Influence of N2O4 on pattern visual evoked potential in winstar mice

AIM: To study the changes of pattern visual evoked potential (PVEP) in Winstar mice after N2O4 injected. ·METHODS: Normal male mice were divided into 3 groups (6-10 in each group): 7.5mg N2O4 group, 15mg N2O4 group and nature solution as normal control. PVEP was recorded at the same time in the evening.SPSS10.0 software was used to analyze the data. ·RESULTS: There were no statistically significant differ-ences of latency and amplitude of PVEP p100 wave as well as their parameters between two test groups and the control group.·CONCLUSION: N2O4 has some influence on PVEP of mice. The degree of the influence is various with the dose of N2O4. This may have positive contribution to further science research.