902例尿培养菌群分布及耐药性分析

目的调查宣城中心医院尿路感染的菌群分布及耐药性,为临床感染预防及合理用药提供依据。方法对安徽省宣城中心医院2010年6月至2012年5月门诊及住院患者尿液的细菌培养、药物敏感试验结果进行总结分析,并与已报道的结果进行比较。结果 902例患者标本共分离出296株(32.8%)病原菌,其中革兰阴性菌178株(60.1%),最常见为大肠埃希菌134株(45.3%),肺炎克雷伯菌18株(6.1%)、变形杆菌12株(4.1%);革兰阳性菌72株(24.3%),最常见为凝固酶阴性葡萄球菌37株(12.5%)及屎肠球菌20株(6.7%);此外还检出真菌46株(15.5%)。结论尿路感染以革兰阴性菌感染较高,真菌的分离率呈上升趋势,不同病原菌敏感药物存在较大差异,建议用药前进行药物敏感性试验。

Distribution and drug resistance of bacteria isolated from 902 cases of cultured urine samples

Objective To investigate tile distribution and drug resistance of bacteria in urine samples of pa- tients with urinary system infection. Methods Detection results of culture and drug sensitivity test of urine samples in this hospital from June 2010 to May 2012 were analyzed. Results 296（32.8%） strains of pathogens were separa- ted from 902 specimens, including 178（60.1%） strains of Gram-negative bacteria, mainly of which was Escherichia coli[134 （45.3 %） ], Klebsiella pneumonia [ 18 （6. 1 %） ] and Bacillus proteus [ 12 （4. 1% ） ], 72 （24. 3 %） strains of Gra,n-positive bacteria, mainly of which were coagulase negative Staphylococcus[37（2.5 % ）] and Enterococcus faeci- um[20（6.7 % ） ], and 46（ 15.5 % ） strains of fungus. Conclusion Gram-negative bacteria might be the most common pathogen in urinary l ract infection, and fungal infection could be with increasing trend. Different pathogens might be with different sensitive drugs. Drug sensitivity test should be applied before the application of antibiotics.