Treatment of previously untreated (by hormonal manipulation) stage D adenocarcinoma of prostate with combined orchiectomy,estrogen, and cis diamminedichloroplatinum

Thirty-four patients with Stage D adenocarcinoma of the prostate previously untreated by hormonal manipulation were treated with the combination of orchiectomy, estrogen therapy, and infusion of cis diamminedichloroplatinum (1 mg./Kg./week) for six weeks initially and every three weeks thereafter. A partial objective response was observed in 22 of 34 patients (64.7 per cent). This response lasted three to twenty-nine months, with an average of 9.3 months. Five patients (14.7 per cent) had a significant decrease or disappearance of bone pain and became ambulatory. Six patients (17.6 per cent) remained stable. One patient (2.9 per cent) did not respond to treatment and showed progression of his disease. The toxicity of the treatment was mild to moderate. Most of the patients were treated in the outpatient department. The combination of cis platinum, orchiectomy, and estrogen therapy appears to be the most effective method of treatment for previously untreated (by hormonal manipulation) Stage D adenocarcinoma of the prostate.