| 16α-甲基-3β,17α-二羟基-5α-孕甾-20酮-3β-醋酸酯的微生物转化 |
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| 引用本文： | 王敬一,张丽青,马如鸿,费得清,游晓燕.16α-甲基-3β,17α-二羟基-5α-孕甾-20酮-3β-醋酸酯的微生物转化[J].药学学报,1987,22(2):141-144. |
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| 作者姓名： | 王敬一 张丽青 马如鸿 费得清 游晓燕 |
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| 作者单位： | 中国科学院上海有机化学研究所;*中国科学院上海生物工程实验基地筹建处;**上海医药工业研究院 |
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| 摘 要： | 16 α-Methyl-3 β,17 α-dihydroxy-5 α-pregnane-20-one-3 β-acetate (Ⅰ) was prepared from tigogenin and then incubated with a mixture of Mycobacterium smegmatis (MS1) and Arthrobacter simplez (A1) to give 16 α-methyl-17 α-hydroxy-△1, 4-pregnadiene-3,20-dione (Ⅱ) with about 63% yield.Compound (Ⅱ) when incubated with Absidia glauca (AG1) gave about 55% yield of 16 α-methyl-11 α, 17 α-dihydroxy-pregna-1,4-diene-3,20-dione (Ⅳ).
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| 关 键 词： | 微生物转化 简单节杆菌 耻垢杆菌 地塞米松 剑麻皂素 |
| 收稿时间： | 1986-01-27 |
Microbial transformation of 16 alpha-methyl-3 beta, 17 alpha-dihydroxy-5 alpha-pregnane-20-one-3 acetate |
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| Wang Jing-Yi,Zhang Li-Qing,Ma Ru-hong,Fci De-Qing and You Xiao-Yan.Microbial transformation of 16 alpha-methyl-3 beta, 17 alpha-dihydroxy-5 alpha-pregnane-20-one-3 acetate[J].Acta Pharmaceutica Sinica,1987,22(2):141-144. |
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| Authors: | Wang Jing-Yi Zhang Li-Qing Ma Ru-hong Fci De-Qing and You Xiao-Yan |
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| Abstract: | 16 α-Methyl-3 β,17 α-dihydroxy-5 α-pregnane-20-one-3 β-acetate (Ⅰ) was prepared from tigogenin and then incubated with a mixture of Mycobacterium smegmatis (MS1) and Arthrobacter simplez (A1) to give 16 α-methyl-17 α-hydroxy-△1, 4-pregnadiene-3,20-dione (Ⅱ) with about 63% yield.Compound (Ⅱ) when incubated with Absidia glauca (AG1) gave about 55% yield of 16 α-methyl-11 α, 17 α-dihydroxy-pregna-1,4-diene-3,20-dione (Ⅳ). |
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| Keywords: | Arthrobacter simplex Mycobaeterium smegematis Dexamethasonc Tigogenin Microbial transformation |
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