脑忆清胶囊对痴呆小鼠自由基代谢的影响

目的：研究脑忆清胶囊对痴呆小鼠自由基代谢的影响。方法：小鼠每日颈背皮下注射5％D－半乳糖0．5ml,40d可造成拟痴呆模型，在注射D－半乳糖的同时，分别灌服脑忆清胶囊混悬液7．0，3．5及1．75g/kg3种剂量，并与脑复康作了比较观察。结果：脑忆清胶囊可明显提高拟痴呆小鼠血液中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH－Px)的活性和脑组织中SOD活性，显著降低拟痴呆小鼠血清、脑中过氧化脂质（LPO）的浓度和脑中单胺氧化酶B（MAO－B）活性，抑制拟痴呆小鼠脑、心、肝、肾组织中脂褐素（LF）的形成。结论：脑忆清胶囊有较好的清除自由基、延缓细胞衰老和改善大脑功能的作用。

Effect of Naoyiqing Capsule on Metabolism of Free Radicals in Dementia Mice

Objective: To study effect of Naoyiqing Capsule on metabolism of free redicals in dementia mice. Methods: The dementia model was induced by subcutaneous injection of 5% D-galactose on the back of the neck of mice 0.5 ml daily for 40 days. Naoyiqing Capsule was given to them orally at the dose of 7.0 , 3.5 and 1.75 g/kg, and was compared with piracetam. Results: It showed that Naoyiqing Capsule significantly increased the activities of SOD, CAT and GSH-Px in blood and the activity of SOD in brain of dementia mice, significantly decreased the concentration of LPO in serum and brain and the activity of MAO-B in brain of dementia mice, greatly inhibited the formation of LF in brain, heart, kidney and liver of dementia mice. Conclusion: These results suggested that Naoyiqing Capsule possess the reliable functions of eliminating free radical, delaying cell aging and improving the function of brain.