| 多位点微透析技术在药代动力学研究中的应用 |
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| 引用本文： | 吴兆恩,王丹巧. 多位点微透析技术在药代动力学研究中的应用[J]. 中国中药杂志, 2010, 35(13): 1765-1768 |
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| 作者姓名： | 吴兆恩 王丹巧 |
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| 作者单位： | 中国中医科学院医学实验中心,北京,100700 |
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| 基金项目： | 国家自然科学基金项目(30772780);中国中医科学院基本科研业务费自主选题项目(ZZ2006037) |
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| 摘 要： | 微透析(MD)作为一种活体生物取样技术,可以在不同组织、不同器官或同一器官不同部位进行化学取样,为阐明药物的体内过程、作用机制以及靶向性提供依据。本文介绍近年来有关多位点微透析技术在药代动力学研究领域中的应用现状和重大进展。
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| 关 键 词： | 多位点微透析 药代动力学 |
| 收稿时间： | 2010-02-24 |
Application of sites-microdialysis technology in pharmacokinetic studies |
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| WU Zhaoen and WANG Danqiao. Application of sites-microdialysis technology in pharmacokinetic studies[J]. China Journal of Chinese Materia Medica, 2010, 35(13): 1765-1768 |
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| Authors: | WU Zhaoen and WANG Danqiao |
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| Affiliation: | Experimental Research Centre, China Academy of Traditional Chinese Medicine, Beijing 100700, China;Experimental Research Centre, China Academy of Traditional Chinese Medicine, Beijing 100700, China |
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| Abstract: | Microdialysis (MD), as a living bio-sampling technique, can be utilizable in different tissues,organs or different parts of the same organs, in order to clarify the drug's pharmacokinetics, mechanism, and provide a basis for targeting. This article describes a number of points in recent years, the microdialysis technique in pharmacokinetic studies in the field of application of the status and significant progress. |
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| Keywords: | sites-microdialysis pharmacokinetic |
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