| 甲睾酮凝胶剂的制备与含量测定 |
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| 引用本文： | 赵映兰,林彩,邓莉,胡斌.甲睾酮凝胶剂的制备与含量测定[J].中国药房,2010(33):3133-3134. |
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| 作者姓名： | 赵映兰 林彩 邓莉 胡斌 |
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| 作者单位： | 第三军医大学西南医院药剂科,重庆市400038 |
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| 摘 要： | 目的:制备甲睾酮凝胶剂,并建立其含量测定方法。方法:以甲睾酮为主药,卡波姆940、67%乙醇、肉豆蔻酸异丙酯等为基质,制备凝胶剂;采用高效液相色谱法测定甲睾酮的含量。结果:所制制剂为澄清透明凝胶;甲睾酮检测浓度的线性范围为2.0～8.0μg·mL-1,平均回收率为99.84%,RSD=0.62%(n=5)。结论:该制剂制备工艺可行,含量测定方法具有较好的专属性和精确度。
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| 关 键 词： | 甲睾酮凝胶剂 制备 含量测定 高效液相色谱法 |
Preparation and Content Determination of Methyltestosterone Gelatin |
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| ZHAO Ying-lan,LIN Cai,DENG Li,HU Bin.Preparation and Content Determination of Methyltestosterone Gelatin[J].China Pharmacy,2010(33):3133-3134. |
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| Authors: | ZHAO Ying-lan LIN Cai DENG Li HU Bin |
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| Institution: | (Dept. of Pharmacy, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China) |
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| Abstract: | OBJECTIVE： To prepare Methyltestosterone gelatin and to establish its content determination method. METHODS： Gelatin was prepared using methyltestosterone as main component and carbomer 940, 67% ethanol and isopropyl myristate as matrix. The content of methyltestosterone was determined by HPLC. RESULTS： Preparation was colorless transparent gelatin. The linear range of methyltestosterone was 2.0～8.0 μg·mL-1 with an average recovery of 99.84% （RSD=0.62%,n=5）. CONCLUSION： Preparation method is practical. The content determination method is specific and accurate. |
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| Keywords: | Methyltestosterone gelatin Preparation Content determination HPLC |
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