还原型谷胱甘肽治疗化疗药物性肝损害的疗效观察

目的:观察还原型谷胱甘肽对于恶性肿瘤患者接受化疗时并发药物性肝损害的治疗作用。方法:将化疗后出现药物性肝损害的85例患者随机分为2组,治疗组(43例)给予还原型谷胱甘肽注射液联合甘草酸二铵注射液治疗;对照组(42例)仅予以甘草酸二铵注射液,观察比较2组患者治疗肝损害的疗效。结果:2周后,治疗组肝功能各指标平均值均低于对照组,2组比较均有显著性差异(P<0.05);治疗组改善临床症状体征及肝功能明显,总有效率达95.3%,与对照组(78.6%)比较有显著性差异(P<0.05)。结论:还原型谷胱甘肽对恶性肿瘤患者化疗药物性肝损害有较好的治疗作用。

Efficacy Observation of Reduced Glutathione in the Treatment of Chemotherapeutics-induced Liver Lesion Caused by Chemotherapy in Cancer Patients

OBJECTIVE：To observe clinical efficacy of reduced glutathione in the treatment of chemotherapeutics-induced liver lesion in cancer patients.METHODS：85 patients with drug-induced liver lesion after chemotherapy were randomly divided into 2 groups.Treatment group were treated with reduced glutathione and diammonium glycyrrhizinate injection （n=43） and control group were treated with diammonium glycyrrhizinate （n=42）.Clinical efficacies of 2 groups were compared.RESULTS：After 2 weeks,average value of several index in treatment group were lower than in control group,there were significant difference between 2 groups （P0.05）.Clinical symptom and liver function of treatment group were improved significantly.Total response rate were 95.3% for treatment group and 78.6% for control group,there were significant difference between 2 groups （P0.05）.CONCLUSION：Reduced glutathione is effective in the treatment of chemotherapeutics-induced liver lesion in patients with malignant tumors.